GlandPlus

buy glandplus singapore

GLANDPLUS

Product Description:

GlandPlus is specially formulated based on the key natural ingredient, Snow Lotus, together with our proprietary premium Edible Bird’s Nest extracts, Olive oil and Coconut oil, working synergistically to regulate hormones production in the body and maintaining a healthy endocrine glands’ functions.

Proprietary Formulation

The unique blend of our proprietary bird’s nest extracts is fortified with snow lotus extract that work synergistically to achieve optimal health and vitality.

Functional Ingredients

The extracts contain rich source of natural high potency bioactive molecules that work at a cellular level to deliver effective responses to our body.

Scientific Expertise

Our expertise in nutritional science incorporates with biotechnology to deliver genuine, safe and effective products to you.​

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Learn more about the All-New C’Neuros here.

major endocrine glands

Major neuroendocrine systems:



  • Hypothalamic–pituitary–adrenal axis (HPA axis)
  • Hypothalamic–pituitary–thyroid axis (HPT axis)
  • Hypothalamic–pituitary–gonadal axis (HPG axis)
  • Hypothalamic–neurohypophyseal system

The nervous and endocrine systems often act together in a process called neuroendocrine integration, to regulate the physiological processes of the human body. Neuroendocrinology arose from the recognition that the brain, especially the hypothalamus, controls secretion of pituitary gland hormones, and has subsequently expanded to investigate numerous interconnections of the endocrine and nervous systems.

 

The neuroendocrine system is the mechanism by which the hypothalamus maintains homeostasis, regulating reproduction, metabolism, eating and drinking behaviour, energy utilization, osmolarity and blood pressure.

 

Therefore, by consuming our supplements regularly, we could achieve complete wellness by assuring optimal hormonal regulation throughout the entire body

stress susceptible

Neuroendocrine mechanisms of stress vulnerability and resilience.

 

  1. Psychological stressors induce the activation of the hypothalamic-pituitary-adrenal axis (HPA), a circuit designed to properly modulate stress response and maintain physiological homeostasis that may be hyperactive in stress-susceptible animals and MDD patients.
  2. Circulating glucocorticoids (GCs), which are synthetized and released from the adrenal glands following HPA activation, can cross the blood–brain barrier through P-glycoprotein (P-gp) transporters of endothelial cells and bind to GC receptors on brain cells including microglia and neurons. Prolonged GC binding on microglial receptors may maintain these CNS-resident immune cells in a pro-inflammatory state leading to the establishment of depression-like behaviors.
  3. Severe early-life stressors, such as maternal separation, can affect GC receptor epigenetic regulation and promote repressive methylation reducing its expression at the cell surface and inducing GC resistance.
  4. GCs play a major role in attenuation of inflammatory response by inducing apoptosis in immune cells, a process that might be involved in stress vulnerability.
  5. Clinical studies reported sex differences in HPA response to stressors. Downregulation of DNA methyltransferase 3a (Dnmt3a) activity may promote resilience in a gender-specific manner by modulating gene expression in stress-related brain regions and possibly HPA axis response. The hormone oxytocin, which plays a role in social bonding, parturition and lactation, can reduce HPA axis activation inducing antidepressant effect.
  6. Low circulating GC level and high expression of GC receptor in brain cells are associated with proper HPA axis response and a resilient phenotype.
  7. Life experience such as high level of maternal care during childhood or exogenous intake of compositions found in proprietary GlandPlusTM can positively alter epigenetic regulation of GC receptor gene, leading to enhanced GC receptor expression in brain and immune cells and reduced stress vulnerability.
  8. Exogenous GC replacement with dehydroepiandrosterone (DHEA), a precursor for the synthesis of anabolic steroids released from the adrenal cortex with cortisol in response to stress or similar compositions found in proprietary GlandPlusTM, may blunt stress-induced HPA axis activation, promoting resilience